World No. 1 · 37 career titles · career win–loss 724–306. Match history, ranking timeline and head-to-head records below.

| Country | Italy |
| Born | 2001 |
| Plays | Diestro |
| Backhand | двуручный |
| Height | 191 cm |
| Win–loss | 724–306 |
| Titles | 37 |
| Grand Slam titles | 5 |
| Masters 1000 | 10 |
| Finals | 11 |
| Ranking | #1 · 11 500 pts |
| Career high | #1 |
Strength 0–100 is our own calculation, not an official tour ranking: 100 is the strongest in history, 70 is about the level of the world No. 100.
| Event · Round | Opponent | Score | Surface | |
|---|---|---|---|---|
| W | Wimbledon · QF | Jan Lennard Struff (GER) | 7-5, 7-6, 6-3 | Grass |
| W | Wimbledon · R16 | Shintaro Mochizuki | 6-3, 7-6(0), 6-3 | |
| W | Wimbledon · R16 | Shintaro Mochizuki | 6-3, 7-6, 6-3 | Grass |
| W | Wimbledon · F | Alexander Zverev (GER) | 6-7, 7-6, 6-3, 6-4 | Grass |
| W | Wimbledon · R64 | Nuno Borges (POR) | 7-6, 7-6, 6-4 | Grass |
| W | Wimbledon · SF | Novak Djokovic (SRB) | 6-4, 6-4, 6-4 | Grass |
| W | Wimbledon · R32 | Jenson Brooksby (USA) | 6-4, 6-3, 6-4 | Grass |
| W | Wimbledon · R128 | Miomir Kecmanovic (SRB) | 4-6, 6-3, 6-7, 6-2, 6-3 | Grass |
| L | Roland Garros · R64 | Juan Manuel Cerundolo | 3-6, 2-6, 7-5, 6-1, 6-1 | Clay |
| L | French Open · R64 | Juan Manuel CERUNDOLO | 3-6, 2-6, 7-5, 6-1, 6-1 | |
| W | Roland Garros · R128 | Clement Tabur (FRA) | 6-1, 6-3, 6-4 | Clay |
| W | Internazionali BNL d'Italia · F | Casper Ruud (NOR) | 6-4, 6-4 | Clay |
| Season | Win–Loss | Titles | Year-end rank |
|---|---|---|---|
| 2026 | 47–7 | 6 | |
| 2025 | 64–7 | 6 | |
| 2024 | 87–13 | 8 | |
| 2023 | 82–30 | 4 | |
| 2022 | 62–25 | 1 | |
| 2021 | 85–36 | 5 | |
| 2020 | 30–26 | 1 | |
| 2019 | 103–37 | 6 | |
| 2018 | 66–53 | ||
| 2017 | 73–52 | ||
| 2016 | 18–13 | ||
| 2015 | 2–1 |